Personally, I think the best solution would be for you to setup a Virtual machine, using whatever you favorite VM tool is, that is as near to identical to your production environment as possible. Same OS, same packages, same configuration and so on.
You are bound to run into other issues as well like slight differences in php, difference in available modules, and so on. A VM that is the same as your production environment will help you be sure you have everything tested right.
Anyway, if a VM isn't an option, you should be able to partition the drive, and create a separate partition using the case-sensitive version of HFS+